Hydroxy Ethyl Cellulose: A Core Excipient In Drugs Formulation

During drugs formulation, excipients are used alongside the active ingredients. They are considered as non-active ingredients. However, they play a vital role in drugs formulation.


Their primary duty is to provide stable-form of dosage in their administration.  It also encapsulates the active ingredients.  


In a case where a wrong excipient is employed, such drug can lead to intoxication.


Hydroxy ethyl cellulose is a perfect example of a suitable and natural excipient accordingly to United States Pharmacopoeia/National Formulary and the European Pharmacopoeia.


It is non-ionic cellulose that can dissolve in water. It is colourless or white, does not have an odour, and it coarse fine-particles flow freely.


However, always consider working with a professional hydroxye thyl cellulose manufacturers for the best product.


Properties of hydroxy ethyl cellulose

The following properties qualify hydroxyl ethyl cellulose as an excipient of high standards among pharmaceutical industries.


· It is pliable or swellable at high temperature; 135 – 140 oC.


· Its  dissolve in water due to the presence of hydrogen bonding in the structure


· It has an adequate thickness.


· It is non-ionic in nature, so it is free from any cationic effect.


· It can be present side-by-side with many substances that dissolve in water, such as salts, surfactant, and polymers.


· It is not toxic nor react with any active ingredients during preparation or after.

 hydroxy ethyl cellulose

 Applications of hydroxy ethyl cellulose in Drugs and foods industries

Some examples of hydroxyl ethyl cellulose in drugs formulation and food are summarized below:


· Sodium ascorbate is condensed, tabletting, and stabilized by using hydroxy ethyl cellulose.


· A thin film of hydroxyl ethyl cellulose and maleic acid styrene polymer sprayed onto pill can be made when it is dissolved in an organic solvent.


· When we look at the delivery method and how to sustain the effect of B12 impact when it is injected intravenously hydroxy ethyl cellulose is employed for this purpose.


· It enhances insecticides that are oily not to harm treasured insect like bees.


· hydroxy ethyl cellulose is an important additive used in ice-cream or refrigerated milk for preservation.


How to use hydroxyl ethyl cellulose

It is generally assumed that hydroxy ethyl cellulose is one of the simplest exudates to be applied. In light of this, hydration must be carried out first to ensure a free flow of the gum.


However, inadequate hydration might bring about abnormality when you introduce other components to the hydrated medium—resulting in generating sludge in the solution.


The gum can be hydrated effectively by employing a good blender or shearer liquidizer. Slowly scatter the coarse fine-particles into the water medium.


As you slowly scatter the fine-particles to the water medium, you will start observing the water medium becoming thick. At this point, you increase the blender’s speed for proper hydration.


It is important to note that you perform the hydration of the gum according to your formulation.


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