Hydroxypropyl methylcellulose (HPMC) is partially ether methylated and ether 2-hydroxyl propylated cellulose. It is produced by reacting raw cellulose with chloroform and propylene oxide.
Its physical properties include tasteless powder, odorless, colorless, and dissolves in cold water. It is a safe and non-toxic excipient in pharmaceuticals because it does not engross orally and doesn't affect foods' vigor.
Apart from having the same properties as other cellulose, it is well-known for its excellent solubility affinity with organic solvents. Because most organic solvents are part of the ingredients in pharmaceutical formulation, these potentials qualified HPMC as a matrix in drug delivery.
However, when sourcing for an excipient such as HPMC for your drug delivery, contacting a reliable and reputable Hydroxypropyl methylcellulose manufacturer will guaranty a pronounced outcome.
Below are general use of HMPC in diverse orderly drug delivery method that any other polymer has not offered.
1. Orderly Releases Dosage Formula
The use of HPMC in orderly release dosage formula are many; they include; a coagulating agent, viscosity, coating cellulose, bio-adhesives, boosts drug solubility when dispersed, binder, etc.
With the right application proportions, cellulose concentration, products' outstanding finishing can be accomplished. Formation of clear, well-matched with dyes, pigment, colors, and sharp coatings is acceptable by the regulatory authority.
Also, HPMC swells up quickly in the target spot and demonstrates the anticipated mechanism of the reaction.
2. It Enhances the Tablet's Physical Properties
It is well-matched with different materials used in tablet production, thereby sustaining the product's shelf life because it acts as an antimicrobial and prevents the tablets' degradation.
In addition, it decreases product flaky by increasing the coating strength if it is from a reliable hydroxypropyl methylcellulose manufacturer.
3. Drug Discharge
HPMC helps in the drug's discharge as the right coating agent, which occurs at a steady rate. Therefore, a constant state of drug discharge is attained, thereby improving the defiance of the patient.
4. Extend Interaction Period
However, to obtain extend precorneal interaction duration and later increase the ocular drug bioavailability. HPMC is used to provide an extended interaction period for the preparation, mainly when applied in the ophthalmic formulation to enhance the drug viscosity.
5. Reaction Mechanism of HPMC
HPMC media provides a drug discharge following the orthodox Higuchi suspension equation, relating the drug's release with root means square of time. The cellulose swelling enables a consistent system having a strong affinity for water. It dissolves a considerable amount of water in the midst of water during gel formation.
As suspension media interact with the matrix, cellulose material starts swelling, and drug particles start moving out of the structure by dispersion or diffusion. It is important to note that Hydroxypropyl methylcellulose manufacturers predict the diffusion range of gel point to range from 50 °C to 90 °C, and it's stable on a broad pH range of 3-1.