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CELOPRE® LS21

CELOPRE® LS21
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CELOPRE® LS21 is a USP/NF pharmacopoeia-grade, low-methoxy, high-hydroxypropoxy K-series HPMC, mainly used in sustained-release tablets and hydrophilic matrix systems. It has good gel-controlled release capability and tableting performance, and is suitable for direct tableting processes.

Test Item Unit Specification Method
Appearance White to Yellowish white Visual
Identification A Conforms USP30 NF25
Identification B Conforms USP30 NF25
Identification C Conforms USP30 NF25
pH 5.0-7.5 USP30 NF25
Loss on drying % 5.0 Max USP30 NF25
Residue on ignition % 0.5 Max USP30 NF25
Chloride % Not more than 0.36 USP30 NF25
Heavy metals % Not more than 0.001 USP30 NF25
Hydroxypropoxyl Content % 10.0 – 12.9 USP30 NF25
Particle size: Retain on 106m Micro 1.0 Max
Pass through 75m Micron 90 Min.

Direct Compression Grade CELOPRE® LS21 Applications

  • Sustained-release & Controlled-release Tablets (SR/CR)

    Sustained-release & Controlled-release Tablets (SR/CR)

    CELOPRE® LS21 can controlling drug release rate by forming a gel barrier.

    Advantages

    • Constructs a stable gel barrier, effectively delaying drug release
    • Precisely regulates release rate, achieving stable blood drug concentrations
    • Accommodates various sustained-release and controlled-release formulation design requirements
    • Ensures consistent drug release and improves formulation reliability
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  • Hydrophilic Matrix Tablet Systems

    Hydrophilic Matrix Tablet Systems

    CELOPRE® LS21 is suitable for hydrophilic matrix tablet systems, featuring adjustable release and high stability.

    Advantages

    • Release profiles can be flexibly adjusted to suit different drug requirements.
    • High matrix stability ensures batch-to-batch drug release consistency.
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  • Tablet Binders

    Tablet Binders

    This product is suitable for structural applications in , CELOPRE® LS21 is applicable to both wet granulation and direct compression, and offers stronger “skeleton strength” compared to the E series.

    Advantages

    • Superior skeleton strength compared to the E series, enhancing interparticle bonding strength
    • Improved tablet mechanical properties, reducing the risk of brittleness
    • Suitable for both wet granulation and direct compression processes
    • Suitable for structural support in high-drug-loading or difficult-to-formulate formulations
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