CELOPRE® LS21 is a USP/NF pharmacopoeia-grade, low-methoxy, high-hydroxypropoxy K-series HPMC, mainly used in sustained-release tablets and hydrophilic matrix systems. It has good gel-controlled release capability and tableting performance, and is suitable for direct tableting processes.
| Test Item | Unit | Specification | Method |
|---|---|---|---|
| Appearance | White to Yellowish white | Visual | |
| Identification A | Conforms | USP30 NF25 | |
| Identification B | Conforms | USP30 NF25 | |
| Identification C | Conforms | USP30 NF25 | |
| pH | 5.0-7.5 | USP30 NF25 | |
| Loss on drying | % | 5.0 Max | USP30 NF25 |
| Residue on ignition | % | 0.5 Max | USP30 NF25 |
| Chloride | % | Not more than 0.36 | USP30 NF25 |
| Heavy metals | % | Not more than 0.001 | USP30 NF25 |
| Hydroxypropoxyl Content | % | 10.0 – 12.9 | USP30 NF25 |
| Particle size: Retain on 106m | Micro | 1.0 Max | |
| Pass through 75m | Micron | 90 Min. |
CELOPRE® LS21 can controlling drug release rate by forming a gel barrier.
CELOPRE® LS21 is suitable for hydrophilic matrix tablet systems, featuring adjustable release and high stability.
This product is suitable for structural applications in , CELOPRE® LS21 is applicable to both wet granulation and direct compression, and offers stronger “skeleton strength” compared to the E series.
